Immediate danger or risk of harm? Call your local emergency number now.

Crisis and urgent help
Do not assume every first episode is purely psychiatric

Sudden psychosis or confusion can be a medical emergency

Surveillance, poisoning, implanted-device, or espionage beliefs can occur during delirium, seizures, neurological illness, infection, endocrine or metabolic problems, medication reactions, intoxication, and withdrawal. The story’s theme does not reveal the cause.

Urgent red flags

Seek prompt medical assessment when any of these are present

One warning sign can be enough to change the safest care setting. Give responders the observable sign and the time it began.

Attention or consciousness changes

  • New disorientation, severe confusion, or inability to follow a simple conversation.
  • Symptoms that fluctuate markedly over minutes or hours.
  • Unusual drowsiness, stupor, reduced responsiveness, or alternating agitation and sleepiness.

Neurological signs

  • First seizure, repeated seizures, collapse, or unexplained periods of lost awareness.
  • New weakness, facial droop, speech difficulty, severe imbalance, or loss of coordination.
  • Severe or unusual headache, recent head injury, vision change, or sudden sensory loss.

Fever, infection, or inflammation

  • Fever, stiff neck, new rash, severe illness, or rapidly worsening physical condition.
  • Recent infection followed by abrupt behavior change, memory problems, seizures, catatonia, or unusual movements.
  • New autonomic instability such as extreme temperature, pulse, or blood-pressure changes.

Movement or catatonia

  • New repetitive facial or body movements, rigidity, tremor, posturing, or severe restlessness.
  • Mutism, staring, inability to initiate movement, unusual resistance, or purposeless excitement.
  • Extreme sensitivity or rapid deterioration after a new psychiatric medicine.

Metabolic or basic-needs failure

  • Not eating or drinking, repeated vomiting, severe dehydration, or inability to take essential medicines.
  • Very low or high blood sugar, severe electrolyte disturbance, kidney or liver failure, or low oxygen.
  • Rapid unexplained weight change, profound weakness, or severe sleep deprivation.

Substance, medication, or withdrawal risk

  • Possible overdose, unknown pill or powder, stimulant binge, synthetic drug, or multiple substances.
  • Alcohol or sedative withdrawal, especially with tremor, sweating, hallucinations, seizure, or confusion.
  • Recent start, stop, or dose increase of steroids, dopamine medicines, anticholinergics, stimulants, or other prescriptions.
Pregnancy and postpartum

New psychosis, mania, or severe confusion after birth needs urgent same-day care

Rapidly developing mission beliefs, paranoia, voices, severe insomnia, agitation, confusion, or unusually elevated mood during pregnancy or after birth should not be managed only with reassurance or a routine future appointment.

  • Do not leave the parent alone with a baby when judgment, reality testing, or impulse control is severely impaired.
  • Tell emergency or maternity services the delivery date, sleep history, mood change, medications, substances, and any thoughts involving self-harm or the baby.
  • Use emergency services immediately for imminent risk; otherwise request urgent perinatal psychiatric assessment the same day.
A useful distinction

Delirium often looks different from a stable psychotic disorder

This comparison is not a self-diagnostic test. Delirium and dementia can coexist with a psychiatric disorder, and a clinician must assess the whole picture.

Feature Delirium or acute encephalopathy Primary psychosis may more often show
Onset Hours to days, often linked to illness, medication, withdrawal, surgery, injury, or metabolic change. May be gradual or acute, but without the defining global attention disturbance of delirium.
Attention Markedly impaired; the person cannot reliably sustain or shift attention. Can be distracted or preoccupied, but basic alertness and attention may be more stable.
Course Fluctuates through the day, sometimes with brief lucid periods. Beliefs and hallucinations may remain more consistent across the day.
Orientation and memory Disorientation and short-term memory failure are common. Orientation can remain intact, especially outside severe disorganization.
Perceptual experiences Visual illusions, vivid visual hallucinations, misidentification, and fragmented fear may dominate. Auditory hallucinations and organized delusional explanations may be more prominent.
Treatment priority Identify and treat the physiological cause while reducing immediate distress and risk. Treat the psychiatric syndrome while still checking for medical and substance-related causes.
Information that changes decisions

What emergency staff need in the first minute

  1. Baseline: What was the person normally like before this change?
  2. Time: When did the change begin, and did it occur suddenly or gradually?
  3. Attention: Are they oriented, awake, and able to follow a conversation?
  4. Physical signs: Fever, seizure, injury, pain, weakness, abnormal movement, pregnancy/postpartum status, or severe sleep loss.
  5. Exposures: Every prescription, over-the-counter medicine, supplement, substance, recent dose change, and withdrawal risk.
  6. Risk: Specific suicidal, violent, escape, confrontation, food-refusal, or command-voice behavior; include access to weapons or vehicles.
Medication and substance checklist

Bring the package, photo, or exact name when possible

  • Prescription name, dose, when started, last dose, missed doses, and recent increases or tapers.
  • Over-the-counter cold, allergy, sleep, pain, or motion-sickness products.
  • Supplements, herbs, energy products, pre-workout products, and weight-loss products.
  • Cannabis potency and route; stimulant, cocaine, hallucinogen, dissociative, or synthetic-drug exposure.
  • Alcohol, benzodiazepine, sedative, or opioid use and the time since the last dose.
  • Any medication taken from another person or substance whose contents are uncertain.

Do not make a dangerous abrupt change

Stopping alcohol, benzodiazepines, some sedatives, corticosteroids, or other prescribed treatments suddenly can worsen illness or create withdrawal risk. For severe symptoms, use emergency or poison services. Otherwise contact the prescriber, pharmacist, or urgent medical service for a supervised plan.

Trusted starting points
Open the complete medical pack
Substances and medical causes Government

Delirium

MedlinePlus

Symptoms, causes, diagnosis, and treatment of delirium.

Substances and medical causes Government

Delirium

National Institute on Aging

Information about sudden confusion and medical causes in older adults.

Substances and medical causes Government

Encephalitis

National Institute of Neurological Disorders and Stroke

Government medical overview of encephalitis.

Substances and medical causes Nonprofit

Autoimmune Encephalitis Alliance

Autoimmune Encephalitis Alliance

Information and support for autoimmune encephalitis, which can present with psychiatric symptoms.

Substances and medical causes Clinical service

Poison Control

America’s Poison Centers

Immediate expert guidance for possible poisoning or medication exposure in the United States.

Substances and medical causes Government

Drug safety communications

U.S. Food and Drug Administration

Official safety alerts for prescription and over-the-counter medicines.

Substances and medical causes Government safety program

MedWatch Safety Information and Adverse Event Reporting

U.S. Food and Drug Administration

Official information for reporting serious medication and medical-product adverse events in the United States.

Note: Do not abruptly stop a prescribed medication unless emergency clinicians advise it; contact the prescriber or urgent care.

Conditions and causes Health service

Postpartum psychosis

NHS

Urgent information about psychosis after childbirth.

Family and supporters Specialist nonprofit

Action on Postpartum Psychosis

Action on Postpartum Psychosis

Specialist information and peer support for people and families affected by postpartum psychosis.

Note: New or rapidly worsening postpartum psychosis symptoms need urgent medical assessment.

Find care / early psychosis Specialist nonprofit

Get Help for Perinatal Mental Health

Postpartum Support International

International and U.S. pathways to perinatal mental-health support, provider directories, and peer resources.

Note: Use emergency services for immediate danger or rapidly developing postpartum psychosis symptoms.

This site supports care; it does not investigate individual claims.

Espionage Psychosis is an educational resource, not a diagnosis, emergency service, law-enforcement service, or substitute for a licensed clinician. Actual stalking, abuse, and privacy violations can occur; serious concerns deserve calm professional assessment without automatically confirming or dismissing them.

Use the two-track safety approach